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Therefore, it really is conceivable that the JIP1/three → ASK1 → MKK4 signaling module may serve as a conduit to activate JNK when endosomal trafficking is disrupted and glucose stages slide in the course of the early levels of methuosis. Our finding that MKK4 was robustly activated by the methuosis-inducing IPPs, MOMIPP and 2q, and les

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